生物医药粤港澳大湾区生产性实训中心

一、平台概况

2020年1月，以深圳职业技术大学食品药品学院为依托单位的生物医药粤港澳大湾区生产性实训中心，经校企双方共同规划建设，正式投入运行。中心建筑面积7000余平方米，建有32个专业化实训单元，配备包括气相色谱三重四极杆质谱联用仪、电感耦合等离子体质谱仪、纳米药物制备系统、波浪式细胞生物反应器、抛弃型袋式细胞生物反应器、全自动微生物分析仪等在内的大型先进仪器设备2000余台套。中心集实践教学、技术研发、社会服务与产业孵化于一体，先后获批“广东省海洋药物产教融合创新平台”“深圳市发酵精制检测系统重点实验室”“深圳市海洋活性物质工程研究中心”“深圳市特医食品工程研究中心”等省市级科研与公共服务平台，硬件设施完备，科研服务基础扎实。

二、平台定位

平台紧扣粤港澳大湾区生物医药产业发展需求，对标全球生物医药技术前沿与区域战略性新兴产业集群建设目标，以产教深度融合为核心路径，致力于建设集实践教学、技术研发、社会服务与产业孵化于一体的高水平生产性实训平台。平台坚持“技术先进、理实一体、虚实结合、智慧管理”的建设理念，聚焦生物医药与精准营养领域的关键技术攻关与高端技术技能人才培养，着力破解从实验室成果到产业化应用的“验证断桥”困境，赋能中小微企业创新发展，服务国家生物医药产业高质量发展与健康中国战略。

三、主要研究方向

平台围绕生物医药与精准营养前沿领域，重点开展以下三个方向的研究：

方向一：药物先导化合物发现与新药创制。依托高分辨质谱室、药物合成室、药理学实验室等，开展天然产物活性成分筛选、小分子药物设计与合成、抗肿瘤疫苗及新型递送系统研发，突破药物合成方法学与制剂关键技术，为创新药物开发提供源头支撑。

方向二：细胞与基因治疗关键技术研发。依托细胞工程实训室、基因工程实训室、发酵精制实训室等，开展动物细胞大规模培养、基因工程菌发酵、细胞治疗产品工艺开发等研究，聚焦新型生物药物的中试放大与工艺优化，推动细胞与基因治疗技术的产业化应用。

方向三：体外诊断试剂开发与食品安全检测技术。依托现代仪器分析实训室、微生物实训室、分离纯化室等，开展体外诊断原材料合成、快速检测方法开发、食品安全风险因子精准识别等研究，为食品安全监管与疾病早期诊断提供技术支撑与标准依据。

四、平台图片展示

五、联系方式

联系人：张丽君

邮箱：c7zlj@szpu.edu.cn

I. Platform Overview

In January 2020, the Biopharmaceutical Production Training Center in the Guangdong-Hong Kong-Macao Greater Bay Area, relying on the School of Food and Pharmaceutical Engineering of Shenzhen Polytechnic University, was officially put into operation following joint planning and construction by the university and enterprise. Covering a construction area of over 7,000 square meters, the center features 32 professional training units and is equipped with more than 2,000 sets of advanced large-scale instruments and equipment, including GC-MS/MS, ICP-MS, nano-drug preparation system, wave-type cell bioreactor, disposable bag-type cell bioreactor, and fully automatic microbial analyzer.

Integrating practical teaching, technological research and development, social services and industrial incubation, the center has successively been approved as provincial and municipal scientific research and public service platforms, such as the Guangdong Provincial Innovation Platform for Industry-Education Integration of Marine Medicines, Shenzhen Key Laboratory of Fermentation and Purification Testing System, Shenzhen Engineering Research Center of Marine Active Substances, and Shenzhen Engineering Research Center of Special Medical Formula Foods. It boasts complete hardware facilities and a solid foundation for scientific research services.  

II. Platform Positioning

Closely aligned with the development needs of the biopharmaceutical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, benchmarking against the global cutting-edge biopharmaceutical technologies and the construction goals of regional strategic emerging industrial clusters, the platform takes in-depth industry-education integration as the core approach. It is committed to building a high-level productive training platform integrating practical teaching, technological R&D, social services and industrial incubation. Adhering to the construction philosophy of "advanced technology, integration of theory and practice, combination of virtuality and reality, and intelligent management", the platform focuses on tackling key technologies and cultivating high-end technical and skilled talents in the fields of biopharmaceuticals and precision nutrition. It strives to bridge the "verification gap" between laboratory achievements and industrial application, empower the innovative development of small, medium and micro enterprises, and serve the high-quality development of the national biopharmaceutical industry and the Healthy China Strategy.  

III. Main Research Directions

Centering on the cutting-edge fields of biopharmaceuticals and precision nutrition, the platform focuses on research in the following three directions:

Direction 1: Discovery of Lead Compounds and Innovative Drug Development

Relying on the High-Resolution Mass Spectrometry Laboratory, Pharmaceutical Synthesis Laboratory, Pharmacology Laboratory and other facilities, it conducts screening of active ingredients from natural products, design and synthesis of small-molecule drugs, as well as R&D of anti-tumor vaccines and novel delivery systems. It breaks through key technologies in pharmaceutical synthesis methodology and preparation, providing source support for innovative drug development.

Direction 2: R&D of Key Technologies for Cell and Gene Therapy

Supported by the Cell Engineering Training Room, Genetic Engineering Training Room, Fermentation and Purification Training Room and other laboratories, it carries out research on large-scale culture of animal cells, fermentation of genetically engineered bacteria, and process development of cell therapy products. Focusing on the pilot scale-up and process optimization of novel biopharmaceuticals, it promotes the industrial application of cell and gene therapy technologies.

Direction 3: Development of In Vitro Diagnostic Reagents and Food Safety Testing Technologies Based on the Modern Instrument Analysis Training Room, Microbiology Training Room, Separation and Purification Laboratory, etc., it conducts research on the synthesis of raw materials for in vitro diagnostics, development of rapid detection methods, and accurate identification of food safety risk factors, providing technical support and standard basis for food safety supervision and early disease diagnosis.

Contact Information

Contact Person: Lijun Zhang

E-mail: c7zlj@szpu.edu.cn