广东省海洋药物产教融合创新平台

一、平台概况

2021年，以深圳职业技术大学食品药品学院为依托单位的广东省海洋药物产教融合创新平台，经广东省教育厅批准正式设立。该平台集海洋新药研发、人才培养、技术转移和成果转化于一体，配备国际先进分析检测仪器与中小试制备制剂设备，构建了完善的海洋药物研发体系与技术服务能力，为海洋生物医药产业创新发展提供坚实支撑。

二、平台定位

平台紧扣国家海洋强国与创新驱动发展战略，对标粤港澳大湾区生物医药产业高质量发展要求，瞄准海洋药物研发领域国际前沿与产业关键技术需求，聚焦海洋天然活性成分研究、天然产物全合成及海洋创新药开发开展高水平应用基础研究与技术攻关。坚持产教融合、校企协同，着力突破海洋新药研发关键核心技术，推动科技成果转移转化与产业化，为深圳及大湾区海洋生物医药产业提质升级提供坚实科技支撑与创新保障。

三、主要研究方向

实验室围绕海洋新药全链条研发需求，聚焦三大核心方向开展科学研究与技术服务，以技术创新支撑产业高质量发展：

1、海洋天然活性成分的功效评价与高效制备依托多组学与机器学习技术构建高效筛选体系，开展海洋生物活性分子发现、结构解析、功效评价及分离纯化技术研究，建立标准化样本库与活性物质制备技术平台，为海洋药物源头创新提供基础支撑。

2、海洋活性天然产物的全合成与生物合成针对结构复杂新颖的海洋生物碱、萜类化合物开展全合成研究，建立高效合成工艺平台，并运用基因工程、发酵工程开展海洋活性分子生物合成与改性研究，突破复杂天然产物制备技术瓶颈。

3、海洋创新药开发与新剂型研究采用计算机辅助药物设计开展分子设计与结构修饰，结合细胞及动物模型开展药效、药代及作用机制研究，搭建纳米制剂、脂质体等新型药物制剂开发平台，全面提升海洋候选药物的成药性与产业化潜力。

四、平台图片展示

五、联系方式

联系人：孙海燕

邮箱：susan@szpu.edu.cn

I. Platform Overview

In 2021, Guangdong Provincial Industry-Education Integration Innovation Platform for Marine Drugs, relying on the School of Food and Pharmaceutical Engineering of Shenzhen Polytechnic University, was officially established with the approval of the Department of Education of Guangdong Province. As an integrated platform for marine drug R&D, talent cultivation, technology transfer and achievement transformation, it is equipped with internationally advanced analytical and testing instruments as well as pilot-scale preparation and formulation equipment. The platform has built a sound system for marine drug research and development and technical service capacity, providing solid support for the innovative development of the marine biomedical industry.

II. Platform Orientation

In line with the national strategies of building a strong marine country and innovation-driven development, and benchmarking the requirements for high-quality development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, the platform targets the international frontier and key industrial technical demands in the field of marine drug R&D. It conducts high-level applied basic research and technical breakthroughs focusing on the research of marine natural active ingredients, total synthesis of natural products, and the development of innovative marine drugs.

Adhering to industry-education integration and university-enterprise collaboration, the platform strives to overcome key core technologies in marine drug R&D, promote the transfer, transformation and industrialization of scientific and technological achievements, and provide solid scientific and technological support and innovative guarantee for the quality improvement and upgrading of the marine biomedical industry in Shenzhen and the Greater Bay Area.

III. Main Research Directions

Centering on the whole-chain R&D demands of marine innovative drugs, the platform carries out scientific research and technical services in three core directions, supporting high-quality industrial development through technological innovation:

Efficacy Evaluation and Efficient Preparation of Marine Natural Active IngredientsRelying on multi-omics and machine learning technologies to construct an efficient screening system, the platform conducts research on the discovery, structural elucidation, efficacy evaluation and separation-purification of marine bioactive molecules. It establishes a standardized sample library and a technical platform for the preparation of active substances, providing fundamental support for the original innovation of marine drugs.

Total Synthesis and Biosynthesis of Bioactive Marine Natural ProductsThe platform carries out total synthesis research on structurally complex and novel marine alkaloids and terpenoids, and establishes an efficient synthetic process platform. It also applies genetic engineering and fermentation engineering to the biosynthesis and modification of marine active molecules, breaking through the technical bottlenecks in the preparation of complex natural products.

Development of Innovative Marine Drugs and Novel Dosage Forms ResearchUsing computer-aided drug design for molecular design and structural modification, the platform conducts studies on pharmacodynamics, pharmacokinetics and mechanism of action combined with cellular and animal models. It builds a development platform for novel drug formulations such as nano-preparations and liposomes, comprehensively improving the druggability and industrialization potential of marine drug candidates.

Contact Information

Contact Person: Haiyan Sun

Email: susan@szpu.edu.cn